Mode of Action of Acridine Antibacterials

Activity and mode of action of acridine compounds against Leishmania donovani.

In the present work, we have assayed both the in vitro and in vivo action of two acridine compounds against Leishmania donovani. As part of this effort, we have studied the possible action mechanism of these compounds at the ultrastructural and biochemical levels and in relation to the synthesis of macromolecules. The two acridinones inhibit the in vitro growth of the promastigote forms of L. d...

evolution and mode of action of pulsed radiofrequency

Mode of Action

Being impermeable to folic acid, many bacteria must rely on their ability to synthesise folate from PABA, Pteridine, and glutamate in contrast the mammalian in cells cannot synthesise folic acid and must obtain preformed folate as a vitamin in their diet. The sulphonamides are structurally similar to PABA, the sulphonamides competitively inhibit dihydropteroate synthetase, the enzyme that catal...

Mode of action of tomaymycin.

The mode of action of tomaymycin (TM) which is a new antibiotic with antitumor activity was studied. Inhibition of the incorporation of labeled precursors into the acid-insoluble fraction of Bacillus subtilis cells indicated that TM inhibits nucleic acids biosynthesis, while having relatively little effect on protein synthesis. TMdisplaced methyl green (MG) from a MG-DNA complex and a TM-DNA co...

Mode of action of antibiotics

An antibiotic is an organic substance produced by a 1)living organism which inhibits the growth of or kills some ,, other living organism. Two. of the more important antibiotic .that have been studied are penicillin and streptomycin. Although three structural formulae for penicillin have been presented, this antibiotic is generally thought of as Ia ring condensation of two amino acids: alanine ...